Identification des mécanismes moléculaires tumoraux et des conditions de l'hôte déterminant l'impact de la diète sur le développement du cancer de la prostate – Découverte de biomarqueurs associés au cancer létal de la prostate et identification de nouvelles cibles thérapeutiques pour intercepter la progression de la maladie

 

David Labbé

Institut de recherche du Centre universitaire de santé McGill

 

Domaine : cancer

Programme Chercheurs-boursiers - Junior 1

Concours 2018-2019

Prostate cancer is a leading cause of cancer-related lethality. Systemic metabolic alterations associated with increased consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression and mortality, but the molecular underpinnings of this association are poorly understood. My research program is aimed at understanding the combination of key tumor genetic alterations together with the host characteristics required for diet to alter prostate cancer progression.

More specifically, my research focuses on the mechanisms and therapeutic targets related to epigenetic alterations and uses murine and human cell lines, animal models (including genetically engineered mouse models) and human tissues. My goal is to identify new therapeutic targets for the treatment of prostate cancer patients at risk of progression to an aggressive, lethal disease.