Glomérulopathies : identification des marqueurs et devenir de la maladie rénale

 

Louis-Philippe Laurin

Centre de recherche de l'Hôpital Maisonneuve-Rosemont

 

Domaine : maladies infectieuses et immunitaires

Programme chercheurs-boursiers-cliniciens  - Junior 1

Concours 2017-2018

Partenaire

Société québécoise de néphorologie (SQN)

Glomerulonephropathies encompass a group of diseases affecting the glomerulus, which constitutes the filter of the kidney. They constitute the cause of end-stage kidney disease in a significant proportion of individuals on dialysis therapy. Glomerular diseases represent heavy and prolonged individual and societal burden as they usually affect younger individuals and are characterized by progression to end-stage kidney disease over a course of several years. Although common in aggregates, they are considered as rare diseases when taken individually.

This heterogeneity and delay in attaining kidney failure has impeded the development of novel therapies through clinical studies. Thus, the establishment of a large cohort of patients with glomerular diseases will fuel research in this field of medicine. My long-term research program falls within the context of studying the epidemiology of glomerulonephropathies. My first project is the expansion of a local registry of patients with glomerular diseases that will serve as platform for recruitment in an international collaborative effort. This large dataset will serve to my second project, a description of clinical trajectories for patients with the most common cause of nephrotic syndrome in adults, focal segmental glomerulosclerosis.

This project involves estimating the incidence of clinically meaningful outcomes and determining risk factors of progression to kidney failure. In conclusion, creation of a comprehensive database of patients with glomerulonephropathies will help physicians to address key questions pertaining to the outcomes and the treatment of those patients.