Facteurs de risques pré et postnataux dans la genèse de la maladie de Crohn pédiatrique et rôle de la vitamine D dans la prévention des rechutes de la maladie et l'amélioration de la qualité de viede maladies chroniques : étude des facteurs causant la non-adhésion et des interventions pour améliorer l'adhésion chez les diabétiques de type 2


Prévost Jantchou

Centre hospitalier universitaire Sainte-Justine


Domaine : maladies infectieuses et immunitaires

Programme chercheurs-boursiers cliniciens - Junior 1

Concours 2014-2015

Crohn's disease (CD) is a chronic relapsing inflammatory bowel disease. In recent years there has been an increase in the incidence of CD in children. This condition is multifactorial (genetic predisposition, environmental factors) A lot of progress has been made regarding the diagnosis and management of CD but currently there is no definitive cure. Our research project has two projects :

1. - Analyze the association between the occurrence of pathological pregnancy (diabetes, hypertension and its complications, newborn infection, prematurity) and the risk of CD in the offspring. To compare the rate of occurrence of MC between the groups of perinatal exposure to these factors, we will use the data obtained from administrative databases in Quebec. Thus, 3000 children with CD will be compared to 30,000 healthy children.

2. - Analyze the beneficial role of vitamin D on the outcome of pediatric CD (relapses and quality of life). Vitamin D is an essential vitamin to the body. In addition to its beneficial effect to the bone, vitamin D exerts an anti-inflammatory effect. We recently initiated a pilot study that allowed us to demonstrate that a dose of 4000 IU / day for a month was safe and enabled us to normalize the blood levels of vitamin D. We are planning to perform a large clinical double-blind trial comparing two doses of vitamin D. Group 1: standard dose of 800 IU per day for 24 months and Group 2: 4,000 IU per day for one month followed by 2,000 IU / day for 23 months. A total of 218 children will be enrolled and followed (relapse, quality of life score) for two years.The results of this study will identify a simple preventive strategy of CD relapse in children and help us improve their quality of life.