Facteurs de risque de présenter une fatigue persistante et invalidante à la suite d'un traumatisme craniocérébral modéré à sévère


Nadia  Gosselin

CIUSSS du Nord-de-l'Île-de-Montréal


Domaine : neurosciences, santé mentale et toxicomanies

Programme consortium pour le développement de la recherche en traumatologie - Volet 1

Concours 2017-2018

Approximately 60% of individuals with a moderate to severe traumatic brain injury (TBI) will present significant fatigue that persists over the years. This fatigue is debilitating, it prevents the return to work or school in 50% of cases, it makes difficult the accomplishment of daily tasks and increases the burden on caregivers. The direct and indirect costs of post-TBI fatigue are enormous. Not all individuals with TBI will develop a persistent and debilitating fatigue. However, we are unable to predict which patients are at risk for significant fatigue in the long-term.

Identify patients at risk would allow the implementation of early interventions to prevent fatigue, a better use of resources in the acute stage and greater efficiency in treatments. This project aims to identify, from the acute phase of moderate to severe TBI, individuals at risk for developing persistent and debilitating fatigue. To achieve this goal, the clinical variables related to TBI, the neuroimaging findings and the absence of 24-h sleep-wake cycle will be measured in the hospitalization phase in tertiary trauma centers. The capacity of these variables to predict fatigue at 12-month post-TBI will be evaluated.

Early identification of patients at risk for fatigue will enable the development of diagnostic tools and targeted interventions from the acute phase of TBI. Ultimately, this project aims at developing clear guidelines for screening of patients at risk of developing disabling fatigue and for early intervention.