Etudes des mécanismes de migration des lymphocytes T-regulateurs à travers la barrière hématoencéphalique afin de développer de nouvelles approches thérapeutiques pour la sclérose en plaque

 

Stephanie Zandee

Centre de recherche du Centre hospitalier de l'Université de Montréal

 

Domaine : neurosciences, santé mentale et toxicomanies

Programme Formation postdoctorale - CITOYENS D'AUTRES PAYS

Concours 2019-2020

Partenaire:

Société canadienne de la sclérose en plaques

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). The CNS is a network of nerve cells that make up the brain and spinal cord. MS activity is a result of self-targeting (harmful) immune cells migrating across the brain blood vessels into the CNS and causing inflammation. Immune cell migration into the CNS does not happen in healthy individuals. In MS, the harmful immune cells mistakenly attack and damage the myelin insulation surrounding the nerves, leading to a variety of clinical symptoms. However, beneficial immune cells (T regulatory cells; or Treg) can also migrate into the CNS. In healthy individuals beneficial Treg help to stop ongoing inflammation in the body.

Currently it is not clear how Treg enter the brain and whether they are able to stop or mistakenly contribute the inflammation in MS plaques. Our goal is to investigate how Treg enter the brain and if they are able to stop the inflammation. This could lead to the use of Treg as a therapy for MS. Moreover, we can learn how to mimic the beneficial effects of Treg to treat MS.