Étude génétique et moléculaire de l'assemblage de l'enveloppe des bactéries à gram-negatif pour l'identification de nouvelles cibles thérapeutiques et le développement d'agents antibactériens afin de faire face au problème de la résistance bactérienne aux antibiotiques

 

Catherine Paradis-Bleau

Université de Montréal

 

Domaine : maladies infectieuses et immunitaires

Programme chercheurs-boursiers - Junio 1

Concours 2014-2015

Bacterial resistance to antibiotics is a serious threat to human health. Many bacteria are now resistant to many classes of antibiotics and this complicates the treatment of bacterial infections. To face this problem and protect human health, we need to develop new classes of antibacterial agents.
 
One of the reasons why bacteria are resistance to antibiotics is because they are protected by a barrier that covers them and blocks the entry of antibiotics. This barrier is called the bacterial envelope and is naturally present in bacteria. I am interested to understand how the bacteria produce this envelope. I also want to understand why the bacterial envelope is so impermeable to antibiotics. This will allow me to develop new antibacterial agents that block the formation of the protective bacterial envelope. This envelope is essential for bacterial survival and preventing its formation will kill the bacteria. I will also develop strategies to increase the permeability of the envelope. In this situation, antibiotics will be able to penetrate the bacterial envelope and reach the bacteria for an effective treatment of bacterial infections.

By preventing the formation of the envelope or by increasing its permeability, my research program should lead to the development of new strategies to combat bacterial infections.