Étude du rôle de la chromatine dans la régulation de l'expression génique chez les eucaryotes

 

François Robert

Institut de recherches cliniques de Montréal [IRCM]

 

Domaine :  organismes vivants

Programme chercheurs-boursiers de mérite

Concours 2017-2018

The Robert laboratory studies the role of chromatin in gene expression. We have different research axes
but they all relate to transcription by RNA polymerase II and its relation to its physiological substrate:
chromatin. Cells take advantage of the plasticity of chromatin and use it as an integral and central part of
gene expression regulation. Indeed, the regulation of transcription involves, in most if not all cases, some
reorganization of chromatin.

More recently, we and others have shown that transcription can influence
chromatin structure. There is therefore a dynamic molecular dialog going on between transcription and
chromatin. We use functional genomic (ChIP-Seq, RNA-Seq, ChIP-chip) and proteomic (mass spectrometry)
approaches in yeast, mammalian cell lines and mice in order to better understand the mechanisms and
consequences of this dialog.