Étude des mécanismes sous-jacents la neurodégénérescence et la neuroprotection axonale dans un modèle de sclérose en plaque via la modulation de microARN in vivo


Junie Barbara Morquette

Centre universitaire de santé McGill [CUSM]


Domaine : santé des populations

Programme : Formation postdoctorale

Concours 2017-2018


Société canadienne de la sclérose en plaques

Nerve fibers are responsible for the communication between different parts of the nervous system. In multiple sclerosis (MS), due to the immune cells which are key actors of inflammation, there is an irreversible damage of nerve fibers. This degeneration leads to neurological impairment such as paralysis and blindness. Using a pre-clinical model of the disease, our preliminary data showed striking evidences of nerve fibers damage in the optic nerve which seemed to correlate with immune cells invasion. However, the way inflammation products negatively affect the neural cells survival and integrity in MS is unknown. But interestingly, regulators of gene expression called miRNAs, which are modulated during inflammation, has recently emerged as targets in therapeutic interventions.

Indeed, previous data in our lab showed the modulation of certain miRNAs during inflammation, either in cell culture or in MS spinal cord neurons, and further evidences have linked these miRNAs to nerve fibers deterioration. In this project, our goal will be: 1) to validate and understand how these identified miRNAs are altered in MS neurons and 2) to investigate how these miRNAs can be controlled to protect against neuronal damage and even potentially induce nerve repairs in MS. Thus, this study will explore a novel approach that will open new avenues for the development of therapeutic strategies for neurodegenerative diseases.