Étude des interactions entre les cellules immunitaires et les composantes de la barrière hématoencéphalique

 

Marie-Ève Janelle

Centre de recherche du CHU de Québec-Université Laval

 

Domaine : neurosciences, santé mentale et toxicomanies

Programme programme d'appui à la recherche pour les enseignants-chercheurs de collège

Concours 2017-2018

Multiple sclerosis (MS) is an autoimmune disease characterized by the presence of inflammatory lesions and demyelination plaques in the brain and spinal cord which has important consequences for patients, such as disability and suffering. An estimated 75 000 Canadians are living with MS which is the highest rates in the world. In patients with MS, the integrity of the blood-brain barrier (BBB) is compromised, allowing immune cells to pass through it.

The cellular and molecular mechanisms underlying the dysfunction of the BBB remain unclear. In the search for effective treatments, investigators should use relevant and representative models of the disease. BBB model can provide a valuable tool for studying mechanistic aspects related to the pathological process of MS and development of neuropharmaceuticals. This work will aim to use our newly developed in vitro BBB model, which is the closest representation of the in vivo situation, to study the impact of immune cells transmigration on the BBB integrity.

This project will allow us to simplify the study of interactions between various cell types present at the BBB level. Finally, this project will allow a better understanding of the MS physiopathology and could lead to very significant contribution to basic research and even clinical opportunities.