Étude des dysfonctions de l'axe microbiote-intestin-cerveau et des différences sexuelles dans un modèle murin de la maladie de Parkinson

 

Jérôme Lamontagne-Proulx

Centre de recherche du CHU de Québec-Université Laval

 

Domaine : neurosciences, santé mentale et toxicomanies

Programme Formation de doctorat

Concours 2019-2020

Partenaire:

Parkinson Canada

Parkinson's disease (PD) is mainly characterized by motor symptoms, such as tremors, bradykinesia and muscle rigidity. However, these motor dysfunctions are usually preceded by other less known non-motor symptoms, such as gastrointestinal dysfunctions. Evidence support the hypothesis that PD could start within the intestine and spread to the brain via the vagus nerve. Of importance, PD incidence is higher in men than women. Various studies show that female sex hormones could slow the progression of the disease and delay the onset of motor symptoms.

This research project aims to study a mouse model of PD with brain and bowel disorders similar to those seen in patients. In addition, some symptoms developed by this model vary according to the sex of the animal. Considering the early onset of non-motor symptoms in patients as well as the hypothesis of a subsequent spread of pathology to the brain, the neural network of the intestine could help us better understand the etiopathogenesis of the disease. In addition, the characterization of male-female differences will allow us to assess the impact of sex hormones on the disease and to validate and discover new drugs.