Étude des comorbidités liées à l'infection par le virus de l'immunodéficience humaine: épidémiologie des complications cardiovasculaires, métaboliques et immunes


Madeleine Durand

Centre de recherche du CHUM


Domaine : santé circulatoire et respiratoire

Programme chercheurs-boursiers cliniciens - Junior 1

Concours 2014-2015

The lives of people living with human immunodeficiency virus (HIV) have greatly changed in the last decade. HIV used to be a deadly disease on the short term. The development of very potent medication to suppress HIV transformed the disease into a long term, manageable condition. However, it appears that although we can halt the progression of HIV to AIDS and death, the virus still takes its toll: people living with HIV develop various chronic complications. Some would say they are aging prematurely.

My research program aims to study in depth various aspects of this premature aging, in particular diseases of the heart and blood vessels, blood sugar regulation, blood clotting, bone health, kidney function, with a focus on immune and genetic factors involved.

In order to do this, we will form a cohort of HIV-positive and HIV-negative patients that we will follow up through time, to observe and study the diseases they develop. These patients will undergo specialized imaging tests to investigate the health of their blood vessels, and we will measure immune and genetic markers in their blood to see if their cardiovascular disease is different from that in patients without HIV. I will also use data that is already collected via the health care system, to measure the frequency of the chronic conditions in HIV patients compared to HIV negative patients.

I hope that this work will provide better solutions for patients living with HIV. If we understand better how the virus affects their global health, we will be better able to prevent and treat diseases, so they can live normal lives.