Étude comparative des circuits neuronaux entre voyants et non-voyants utilisant simultanément l'IRM de structure et de diffusion


Raquel del Carpio

Centre universitaire de santé McGill (CUSM)


Domaine : Neurosciences, santé mentale et toxicomanies

Programme : Recherches en radiologie

Concours 2016-2017

Traumatic brain injury (TBI) is one of the most prevalent neurological disorders in North America. 75-85 % of these injuries are categorized as mild (mTBI) and in most individuals the cognitive and physical symptoms resolve within 3 months post-injury.In 15-30 % of these patients, however, significant cognitive, emotional, and functional disturbances persist. Because of its high prevalence in the population, this group of patients represents a great challenge for accurate diagnosis, outcome prediction and treatment options. In spite of the presence of post concussive symptoms, the brains of these individuals appear normal with conventional imaging tools such as Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) and the presence of diffuse axonal injury (DAI) is commonly missed.

The diagnostic and prognostic tools for risk estimation in these patients is therefore quite limited and there is a need for further investigation with advanced neuroimaging techniques to better portray mTBI. Resting state functional MRI (rsfMRI)is one tool which can characterize the interactions both within and between networks in the brain.The other is Diffusion Tensor Imaging (DTI) used to determine integrity of the white matter of the brain.These techniques could potentially provide additional insight with regard to the extent of brain damage in mTBI and aid clinicians in predicting the long-term outcomes in these patients.