Étienne Marc Jolicoeur

Centre de recherche de l'Institut de cardiologie de Montréal


Domaine : Santé circulatoire et respiratoire

Programme chercheurs-boursiers cliniciens - Junior 2

Concours 2016-2017

A heart attack occurs when an artery is blocked by a blood clot. Coronary stents are used to unblock arteries and treat heart attacks. These stents can move clots in the arteries and thus worsen the damages. Whether there stents needs to be implemented immediately is controversial. In practice, the delayed implantation of stents may allow the clot to melt away and prevent damage. The PRIMACY clinical trial will compare the immediate vs. the delayed implantation of stents in heart attacks.

Stenosed aortic valves can now be treated through a small hole in the skin, via the artery in the leg all the way up to the heart. This treatment is minimally invasive and has revolutionized the treatment of severe aortic stenosis. However, the passage through the artery of the leg can still cause major complications such as bleeding or stroke. An alternative approach to the leg is the direct aortic approach. This approach may potentially minimize complications but requires a minor surgery. The PUZZLE trial is set to compare both approaches.

The randomized-registry trial (RRT) could revolutionize the way clinical trials are conducted. The RRT typically link clinical registries to health administrative databases (HAD). We want to determine the correlation between clinical events captured by provincial HAD and concurrent events reported in clinical trials for more than 20,000 Canadians who participated in clinical trials.