Effets neuroprotecteurs et mécanismes neuronaux du miR-223 dans la sclérose en plaques

 

Yang Zhang

Centre universitaire de santé McGill [CUSM]

 

Domaine : Neurosciences, santé mentale et toxicomanies

Programme : Formation de maîtrise

Concours 2017-2018

Partenaire:

Société canadienne de la sclérose en plaques

Multiple sclerosis (MS) is an autoimmune disorder where immune cells attack the insulating myelin sheaths of neurons. This demyelination process contributes to damage in neurons and their axon processes. Neuron degeneration is considered to be the major cause of disabilities experienced by patients as axon loss is correlated with clinical score. Therapies that aim to prevent or repair this damage would be beneficial in controlling the progression of disease in the long term. MicroRNAs (miRNAs) are small molecules in cells that act as regulators of many important processes. The levels of various miRNAs are altered in degenerating neurons in MS and this can lead to significant changes within the cell.

Our lab has previously characterized a miRNA, miR-223, as having protective effects in neurons against immune driven damage. We expect to further investigate miR-223 by characterizing the mechanisms behind these protective effects. We will also investigate if miR-223 can influence the course of disease in an animal model of MS. With this work, we hope to bring insight to the cellular processes behind neuron degeneration in MS and contribute towards development of improved therapies for MS patients.