Effet du traitement par pression positive continue (PPC) sur les troubles respiratoires du sommeil maternels et les issues cardiométaboliques

 

Sushmita Pamidi

Institut de recherche du Centre universitaire de santé McGill (CUSM)

 

Domaine : Santé circulatoire et respiratoire

Programme chercheurs-boursiers cliniciens - Junior 1

Concours 2016-2017

Symptoms of sleep apnea, such as snoring and breathing pauses, are common in pregnancy.  In sleep apnea, intermittent breathing pauses during sleep occur, and accumulating evidence has been linking maternal sleep apnea to poor health for the mother and fetus.  Gestational diabetes is one such poor outcome and is defined as high blood sugar that is first recognized during pregnancy, and can lead to fetal death, delivery of large babies, and consequently, birth injuries and higher rates of caesarean section.  Also, gestational diabetes can result in a ~50% risk of diabetes for the mother later in life, in addition to childhood obesity and diabetes for the infant.  Although we have shown that treatment of sleep apnea with the most common treatment, continuous positive airway pressure (CPAP), improves blood sugar levels in non-pregnant patients, no studies have tried treating sleep apnea in pregnancy to see if blood sugar control or other outcomes will improve. 

As such, my research program will involve studying pregnant participants who are risk of adverse outcomes, and randomizing them to CPAP or a control if they test positive for sleep apnea using home sleep studies. Our main aims are to test if women can adhere to CPAP, and to determine if glucose levels and maternal-fetal outcomes are improved in the CPAP group compared to the control group.  The results of this study will help us determine if we should be routinely screening for sleep apnea among high risk pregnant patients in order to decrease the incidence of poor outcomes for the mother and fetus.