Dysfonction des cellules endothéliales progénitrices dans le développement de maladies cardiovasculaires suite à une naissance prématurée : une approche translationnelle


Camille Girard-Bock

Centre de recherche du CHU Sainte-Justine


Domaine : Santé circulatoire et respiratoire

Programme : Formation de doctorat

Concours 2017-2018


Fondation des maladies du coeur et de l'AVC du Québec

In Canada, 8% of births are preterm (< 37 weeks) and 1% occur < 29 weeks. Preterm born survivors are at
increased risk for cardiovascular diseases. How this exactly happens remains unclear. Endothelial progenitor cells (EPCs) come from the bone marrow and migrate to blood vessels where they participate in vascular (blood vessel) growth and repair. They are very important to maintain good vascular health. EPCs are decreased and poorly functioning in adults at risk for cardiovascular diseases. Factors known to affect EPCs are inflammation and oxidative stress. It is also recognized that preterm babies are exposed to inflammation and oxidative stress.

Moreover, there is now evidence that EPCs from preterm neonates are impaired. Whether EPCs are still impaired in adulthood and could contribute to poor cardiovascular health needs to be proven. The goal of current study is to examine endothelial progenitor cells in relation to inflammation/oxidative stress and cardiovascular function following preterm birth in human adults and following high oxygen (O2) exposure in a rat model mimicking conditions related to prematurity.