Du sildénafil pour réparer les cerveaux des bébés qui ont souffert d'asphyxie à la naissance

 

Armin Yazdani

Institut de recherche du Centre universitaire de santé McGill (CUSM)

 

Domaine : Santé de la mère, des enfants et des adolescents

Programme : Formation de doctorat

Concours 2016-2017

Partenaire:

Fondation des Étoiles

Some babies are at risk of having brain damages, since they did not receive enough oxygen and blood to the brain and other body organs around the time of their birth (asphyxia). The risk of death or long-term neurological sequelae such as cerebral palsy in these babies is very high. Cooling the entire body is the only available treatment for these babies to try to prevent the development of brain damages in these infants. However, this treatment works well with some babies, but not for others. Many babies suffering from asphyxia at birth still develop brain damage despite the cooling treatment.

No treatment currently exists to repair the damages to the brain. The aim of my research project is to test and better understand the potential role of sildenafil to repair the brains of babies who suffered from asphyxia at birth. The initial results of my research suggest that not only can sildenafil reduces the size of the brain damages and increase the number of brain cells, but it also reduces the inflammation that is bad for the brain. In my next experiments, I will test the effect of sildenafil in combination with cooling to see if the effect is even more beneficial; and I will also explore in more detail how sildenafil acts on the brains of babies.

These data should help to plan additional treatments in babies who have suffered from asphyxia at birth to reduce their damages to their brain and therefore improve their future development.