Développement de nouvelles technologies pour l'exploration génomique et la modification des populations bactériennes

 

Sébastien Rodrigue

Université de Sherbrooke

 

Domaine : Génétique humaine

Programme chercheurs-boursiers - Junior 2

Concours 2016-2017


Bacteria outnumber human cells by a factor of ten in our body. Still, we do not know the exact nature of many inhabitants of our microbiome since only about 1% of bacteria can be grown under laboratory conditions to be studied. Yet, certain of these microbes can cause potentially deadly infections that are in many cases becoming harder to cure due to the increase in multidrug resistance.

This project's first objective is to allow the development of new ultra-high throughput methods to quickly identify interesting bacteria and sequence their genome. Genome sequencing is a powerful approach that can rapidly provide insights about the lifestyle and genetic capacity of a microorganism.

The second objective is to develop innovative solutions to fight microbial pathogens by engineer a probiotic strain to detect and specifically eliminate undesirable microbes. These technologies could eventually play an important role in the diagnostics and treatment of infectious diseases.