Conception de nouveaux agents anticancéreux ciblant les mécanismes de réparation et de réplication de l'ADN en vue de leur utilisation en médecine personnalisée

 

Sébastien Fortin

Centre hospitalier universitaire de Québec

 

Domaine : cancer

Programme Chercheurs-boursiers - Junior 1

Concours 2018-2019

In Canada, cancer is the leading cause of death only followed by cardiovascular diseases. Cancer is therefore a major public health problem. Despite recent medical breakthroughs, the ability of curing all cancer patients remains difficult. Consequently, we need to develop new treatments that will be more efficient, more selective against cancer tumors with the aim of improving the life expectancy and the quality of life of cancer patients. To that end, we have recently discovered two new families of anticancer agents. They block a number of very precise mechanisms that are required to repair/replicate our DNA on a daily basis. My research program is divided into two projects. These projects are to develop two new families of drug capable of blocking DNA reparation/replication mechanisms. Inhibition of such mechanisms will not only kill cancer cells but also improve the efficiency of other anticancer drugs and radiotherapy. Therefore, lower doses of drugs or radiation will be required and thus side effects will be also lowered.

My research program will be using methods and tools for chemistry and biology to design and prepare the new drugs that will be tested in various conditions to identify the most promising ones for experiments on animal bearing cancer tumors and hopefully for clinical trials. My endeavour is expected to generate new anticancer drugs more effective that will improve the life expectancy and the quality of life of cancer patients.