Compréhension de la pathogénèse des maladies neurodégénératives et développement de stratégies thérapeutiques

 

Francesca Cicchetti

Centre de recherche du CHU de Québec-Université Laval

 

Domaine : neurosciences, santé mentale et toxicomanies

Programme  chaires de recherche

Concours 2017-2018

Our research program is built on 3 distinct research themes: 1) to better understand the phenomenon that may contribute to the development or the propagation of pathological aspects found in neurodegenerative diseases (in particular Parkinson and Huntington) and related-cognitive features; 2) develop therapeutic strategies that would allow an early or late intervention in the evolution of the disease; 3) study the mechanisms of action underlying the beneficial and/or detrimental effects of current experimental therapies (cell transplantation and deep brain stimulation) in order to improve these methodologies for the clinic.

Our research program is based on translational research, from the animal model to the clinic, with the goal to develop novel therapeutic targets for individuals suffering from Parkinson and/or Huntington's diseases. With this research program, we have developed a considerable expertise in animal models of these diseases, in imaging/microscopy in small animal but importantly in the histopathological analyses of human tissue.

Our collaborations with various clinicians are providing us invaluable access to human samples (blood, spinal cord and brain), at times extremely rare (ex: brains of transplanted patients). Various pharmaceutical/industrial partners with whom we also collaborate will help us accelerate our findings to tangible clinical applications.