Comment identifier précocément les nouveau-nés à risque de développer des lésions cérébrales malgré le traitement par hypothermie

Chercheurs-boursiers cliniciens- Junior 1 | Concours 2012-2013

Pia Wintermark

Institut de recherche du Centre universitaire de santé McGill (CUSM)


Domaine : Santé de la mère, des enfants et des adolescents 

Some babies are at risk of having brain injury, as they did not receive enough blood supply and oxygen to their brain in the body around the time of birth to keep them healthy (asphyxia). The risk of death or neurological sequelae such as cerebral palsy in these babies is high. Total body cooling is a new standard of care in these babies, but much remains in understanding why this treatment works in some babies and why it does not in other.
My preliminary data suggests that those babies who will develop brain injury despite cooling may be indentified in the first days of life by measuring brain blood flow in the brain. Additional studies with larger numbers of patients are required to confirm these results.
The goal of this research program is to better understand how brain injury develop in these babies, by measuring abnormalities of blood flow in the brain using magnetic resonance imaging and bedside monitoring (near-infrared spectroscopy). The specific aims of this study are (1) to learn more details about the temporal evolution of brain blood flow during the first month of life in asphyxiated newborns treated with cooling, and (2) to determine if the early blood flow abnormalities during the first days of life can predict the future brain injury in these babies, and thus their later neurodevelopmental outcome.
These data will permit to identify as soon as possible the babies at risk of developing brain injury despite cooling treatment. This will permit to guide the tailoring of the treatment in these babies, in order to decrease brain injury in these babies, and thus improve their future neurodevelopmental outcome.