Changements génétiques et épigénétiques des cellules germinales, tumorales et du stroma dans les adénomes pancréatiques

Chercheurs-boursiers cliniciens- Junior 1 | Concours 2012-2013

George Zogopoulos

Institut de recherche du Centre universitaire de santé McGill (CUSM)


Domaine : Cancer

Pancreatic cancer is one of the most devastating cancers, with cure rates of only 1-3%. Most cases occur without a family history of this disease. However, 5-10% of cases concentrate in families and only a small component of inherited pancreatic cancer is explained by known genetic syndromes, leaving the genetic changes responsible for the majority of cases of familial pancreatic cancer unknown.

We believe that specific hereditary genetic changes increase the life time risk of developing pancreatic cancer and that, together with molecular changes that occur in the tumour and in the microenvironment surrounding the tumour, these hereditary genetic changes contribute to the progression of the disease and its therapeutic resistance. 


Unfortunately, pancreatic cancer research has been hindered due to a lack of information about patients with pancreatic cancer and to a lack of specimens from patients with this disease. To address this, we will develop the Québec Pancreas Cancer Study. This essential resource for the study of pancreatic cancer in Québec will consist of carefully collected of medical, hereditary and environmental information from patients with pancreatic cancer. In addition, specimens will be collected from these individuals to search for the hereditary genetic changes responsible for pancreatic cancer, to study the tumour biology of this cancer, to develop early disease detection programs, and to test new drugs. The Québec Pancreas Cancer Study will provide patients with opportunities to participate in a local pancreatic cancer research program and to enrol in investigational early disease screening programs.