Caractérisation des complexes protéiques essentiels à la biologie des centrosomes et à la santé humaine

 

William Tsang

Institut de recherches cliniques de Montréal [IRCM]

 

Domaine :   cancer

Programme chercheurs-boursiers - Junior 2

Concours 2017-2018

Cell division is a fundamental biological process that occurs in all organisms. It is governed by a highly sophisticated sequence of events involving hundreds to thousands of proteins working day and night. One malfunctioning protein is enough to trigger a breakdown in cell division, leading to different phenotypic outcomes including cell death, growth arrest or uncontrolled proliferation. The research interest of Dr. William Tsang focuses on understanding the biology of a specialized subunit within a cell called the centrosome which plays a pivotal role in cell division.

The centrosome contains many different proteins, but only some have been extensively characterized. Importantly, mutations in genes that encode centrosomal proteins are known to cause cancer, birth defects, developmental disorders and a wide spectrum of genetic disorders. My laboratory uses innovative and cutting-edge technologies to identify novel proteins relevant to centrosome biology and to study how they communicate with each other. By understanding the function of these proteins, we will begin to understand the mechanisms underlying human diseases resulting from mutations that cripple centrosome function and the phenotypes associated with these diseases.