Allergies aux aliments et aux médicaments: anaphylaxie, taux, causes, gestion et désensibilisation

 

Moshe Ben-Shoshan

Institut de recherche du Centre universitaire de santé McGill

 

Domaine : santé de la mère, des enfants et des adolescents

Programme Chercheurs-boursiers cliniciens - Junior 2

Concours 2019-2020

Anaphylaxis  affects almost 600,000 Canadians. The main triggers of anaphylaxis are food and drug allergy. I will aim in the following five years to determine the causes of food and drug allergy in order to reduce the risk of developing anaphylaxis. In addition, for those who are already diagnosed with food and drug allergy, I will develop management protocols that will reduce the risk of developing life-threatening reactions.

I have established four studies in order to address the above goals:

  1. My group actively collects data from the largest world-wide study of children reporting antibiotic allergy. All participants presenting to allergy clinics are investigated by introducing the suspected antibiotic under the supervision of an allergist.  
  2. Over the past 7 years, I have followed approximately 4000 anaphylaxis cases treated in emergency departments across Canada. I will use the information collected in this registry to evaluate if early epinephrine use +/- antihistamines/steroids will reduce the risk of severe consequences including admission to the hospital or the intensive care unit.
  3. In 2013, my group developed the first Canadian desensitization protocols for milk, and more recently for peanut, tree nut and egg.
  4. My fourth initiative aims to bridge knowledge gaps related to the management of severe allergies through the  development of a short interactive educational videos and by  updating current emergency department guidelines on the management of anaphylaxis based on the Canadian experience.

In conclusion, my research program will help develop safer management protocols for Canadians with severe allergies