The Douglas Hospital Research Centre



Dr Gustavo Turecki


6875, boulevard LaSalle
Verdun (Québec)
H4H 1R3
(514) 761-6131


Research areas : 4

Researchers : 67


In collaboration with people living with mental health problems, their families, and the community, the mission of the Douglas Mental Health University Institute is to offer cutting-edge care and services and to advance and share knowledge in mental health.

Research areas Research themes

Schizophrenia and neurodevelopmental disorders

Principal investigator:
Ridha Joober

  • Pharmacogenetic study of attention deficit-hyperactivity disorder (ADHD / hyperactivity component)
  • Prenatal and perinatal trauma and ADHD
  • Efficacy of social skills program
  • Risk and protection factors for children with severe behavioural disorders
  • Neuropsychology of children with learning disorders and ADHD
  • Borderline conditions in children
  • Early indicator of regressive autism
  • Early environmental determinants and neurodevelopment of dopamine (DA) function
  • Psychosocial rehabilitation for severe mental disorders
  • Influence of maternal care on gene expression and development of individual responses to stress
  • Schizophrenia development mechanisms: development and regulation of dopamine transmission and behavioural influence
  • Neurobiology of mother-child regulation
  • Neurobiology and psychosocial components of schizophrenia: animal model, genetics, dopamine function, brain imaging, neurophysiology (evoked potentials, eye-tracking), neuropsychology, pharmacotherapy, psychosocial stressors, influence of culture and gender, quality of life, evaluation of care and services

Services, policies and population health

Principal investigator:
Alain Brunet

  • Evaluation of policies and services
  • Epidemiological and community studies
  • Development of tools and methodology
  • Mental health in a transnational world

Anxiety, mood and impulsivity disorders

Principal investigator:
Naguib Mechawar

  • Evaluation of rehabilitation therapies and programs
  • Identification of biological and genetic markers of predisposition
  • Mechanisms underlying the desire to consume
  • Transfer of evaluation and intervention technologies in frontline environments
  • Drug dependence and aggression, conjugal violence
  • Psychopharmacological adjuvants in treatment of alcoholism
  • Attention deficits in anxiety disorders and depression
  • Roles of hypothalamic-pituitary-adrenal (HPA) axis in unipolar and bipolar depression
  • Evaluation of antidepressant efficacy
  • Circadian rhythms, depression and affective disorders
  • Specialized therapy for bipolar affective disorders
  • Animal models of affective diseases
  • Serotonin functions in eating disorders
  • Clinical and neurobiological implications of developmental trauma in attentive disorders (AD)
  • Role of comorbid impulsivity in AD
  • Studies on antecedents and sequelae of disturbed eating behaviour in clinical and non-clinical populations
  • Responses to specialized therapies
  • Neurobiology and psychosocial components of post-traumatic stress disorder
  • Molecular mechanisms of circadian clocks
  • Neuroimmunology of cytokines in disease
  • Collective trauma
  • Trauma-related disorders
  • Antidepressant action mechanisms
  • Molecular genetic studies on eating disorders

Aging and Alzheimer's disease

Principal investigator:
Judes Poirier

  • Genetic components of dementia
  • Link between stress, depression and dementia
  • Neurobiology of dementia
  • Clinical trials on new dementia drugs
  • Alzheimer's disease diagnosis and treatment
  • Intervention for natural caregivers
  • Role of inflammation associated with Alzheimer's disease

*The mission comes from the centre's website.