PhD student in Neurology and Neurosurgery
The Research Institute of the McGill University Health Centre
Award-winning publication: Clock-driven vasopressin neurotransmission mediates anticipatory thirst prior to sleep
Published in: Nature
Claire Gizowski's study provides the first clearly detailed example of how the brain's master circadian clock can directly regulate a circadian behaviour. In addition, it identifies a novel circadian behaviour. Understanding the key basic mechanisms that underlie clock function and clock-controlled circadian behaviours can lead to the development of better and more effective treatments to treat the consequences of shift work, as well as jet-lag. This paper thus advances the knowledge of the brain, expands the understanding of a specific behaviour not previously described (anticipatory thirst), and has the potential to lead to innovative treatment strategies.