PhD student in Human Genetics
Award-winning publication: Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study
Published in: The British Medical Journal
Osteoporosis is a common and debilitating disease associated with age that causes bones to thin and become more porous, leading to an increased risk of fracture. Bone mineral density (BMD)—the most clinically relevant risk factor for osteoporosis— is highly hereditary, and genetics therefore play a critical role in bone health. To study the genetic aspects of fracture risk, John Morris led a genetic association study to identify the genes that influence the risk of osteoporotic fractures. "Mendelian randomization" studiess of 14 clinical risk factors for fracture confirm that confirm that decreased BMD is the key cause of osteoporotic fractures and that the most effective clinical interventions to prevent fractures are those that aim to increase BMD.