Relève étoile Jacques-Genest 
January 2019

Daphné Génier Marchand

PhD student in psychology
Université du Québec à Montréal, Sacré-Cœur Hospital Research Centre

Award-winning publicationHow does dementia with Lewy bodies start? Prodromal cognitive changes in REM sleep behavior disorder

Published in: Annals of Neurology


Pathological aging constitutes a key social issue that requires adjustments to the organization of health care. Parkinson's disease (PD) and Lewy body dementia (LBD) are two common neurodegenerative diseases that share a same pathophysiology, leading to the progressive development of motor, cognitive, sleep and psychological impairments. In this study, Daphné Génier Marchand assessed the evolution of cognitive impairments in patients who suffered from an REM sleep behaviour disorder (RSBD) in the years prior to their PD or LBD diagnosis. The results show that early impairments in attention or executive functions in RSBD patients are associated with the subsequent development of dementia. The findings could eventually support the launch of clinical trials to prevent cognitive decline in individuals who are at risk of developing a neurodegenerative disease.