Victor Chichkov and Victoria Zismanov
M.Sc students in Human Genetics
Lady Davis Institute
Award-winning publication: Phosphorylation of eIF2α Is a Translational Control Mechanism Regulating Muscle Stem Cell Quiescence and Self-Renewal
Published in: Cell Stem Cell
Certain muscles cells are able to activate to repair muscle tissue when a major injury occurs. The article by Victor Chichkov and Victoria Zismanov is the first to reveal that adult stem cells rely on a gene translation control mechanism to sustain their regenerative capacity. The researchers also demonstrated the possibility of using an inhibiting molecule to manipulate the mechanism to preserve and potentially promote the self-renewal of the cells under culture conditions. While the work is focused on muscle stem cells, the researchers suggest that the mechanism could play a significant role in other types of tissue and even in cancer stem cells.