Étudiante-chercheuse étoile October 2012



Geneviève Oligny Longpré

Student in Medicine and PhD student in Biochemistry
Université de Montréal


Award-winning publication: Engagement of β-arrestin by transactivated insulin-like growth factor receptor is needed for V2 vasopressin receptor-stimulated ERK1/2 activation

Published in: Proceedings of the National Academy of Sciences of the USA
 

Abstract

"G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) constitute the two largest membrane protein families involved in cell membrane signal transduction. However, little is known about the interactions between the two receptor classes. Using the V2 receptor (V2R) as a GPCR model, we describe a new ERK pathway activation mechanism based on the transactivation of the insulin-like growth factor receptor (IGFR), an RTK, by V2R. We demonstrated that V2R stimulates the ERK pathway by generating an extracellular ligand able to activate the IGFR in an autocrine manner and confirmed the existence of the mechanism in vivo in rats."

Given the recognized role of the ERK pathway (kinase regulated by extracellular signal) in controlling cell growth and proliferation, V2R-activated ERKs could be involved in oncogenic processes in the kidney. Interestingly, V2R and IGFR are therapeutic targets in the treatment of polycystic kidney disease and renal cancer. Examining the pathophysiological roles of this new signal pathway could elucidate the molecular basis of certain kidney diseases and lead to the development of new treatments.