Étudiant-chercheur étoile September 2013

Luis Nombela Franco

Postdoctoral fellow in Cardiology
Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval

Award-winning publication: Timing, predictive factors, and prognostic value of cerebrovascular events in a large cohort of patients undergoing transcatheter aortic valve implantation

Published in: Circulation, 126(25), 3041-53.


"TAVI is an aortic valve replacement technique that is commonly performed on inoperable patients suffering from severe aortic stenosis and constitutes an alternative to surgical valve replacement in high-risk patients. My study determined that in a cohort of 1 000 patients, 1 in 20 experienced a cardiovascular event (CVE) in the 30 days following the procedure and half of the incidents occurred immediately after or in the hours following the operation. I also demonstrated that acute CVEs (those occurring less than 24 hours after the procedure) were most often linked to mechanical factors (e.g. valve dislodging or embolization)."

This study is the first to set out time-related CVE predictors and provides useful data on the pathological mechanisms of this serious complication in patients who have undergone TAVI. Preventive measures are suggested for each period following the procedure to reduce the overall CVE rate. Luis Nombela Franco's publication is the first to report that major strokes occurring after TAVI often lead to mortality, highlighting the importance of curbing its incidence. The research therefore focuses on the implementation of more adequate measures to control the high risk of CVEs associated with such procedures.