PhD student in Physiology
Award-winning publication: Serine Is an Essential Metabolite for Effector T Cell Expansion
Published in: Cell Metabolism
Eric Ma's observations suggest that the expansion of T effector cells can be lowered through manipulation of serine in the diet. This is innovating in the field of immunometabolism, as the majority of the focus has been on glucose metabolism so far. Using 13C metabolite and GC/LC-MS techniques, the author highlights the importance of other metabolic pathways. The article notably presents serine metabolism as an intrinsic regulator of T cell proliferation, independent of glucose and glutamine metabolism. These major findings could eventually spur new avenues for developing stronger anti-tumor cell responses and trigger an increase in the number of tumor killing T lymphocytes.